Submitting a grant proposal to the National Science Foundation (NSF) requires careful planning and organization. This guide provides an overview of the essential steps for a successful NSF Grant Submission, including the importance of updating key documents such as the biosketch, current and pending support, collaborators and other affiliations, and synergistic activities. It also offers a detailed checklist to ensure that all necessary components are in place, from the Data Management and Sharing Plan to compliance with NSF’s guidelines. Pre-planning and regular updates will help streamline the process, increasing your chances of securing funding.